Toll-like receptor 2 is required for opioids-induced neuronal apoptosis
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چکیده
منابع مشابه
Toll-Like Receptor 9 Is Required for Opioid-Induced Microglia Apoptosis
Opioids have been widely applied in clinics as one of the most potent pain relievers for centuries, but their abuse has deleterious physiological effects beyond addiction. However, the underlying mechanism by which microglia in response to opioids remains largely unknown. Here we show that morphine induces the expression of Toll-like receptor 9 (TLR9), a key mediator of innate immunity and infl...
متن کاملPlexin-A4–semaphorin 3A signaling is required for Toll-like receptor– and sepsis-induced cytokine storm
Plexins and semaphorins are ligand-receptor pairs that serve as guidance molecules in the nervous system and play some roles in immunity. Plexins are similar to the Toll-like receptors (TLRs) in their evolutionary conservation from flies to mammals. By studying plexin-A4-deficient (Plxna4(-/-)) innate immune cells, in this study we show a novel influence of plexin-A4 on TLR signaling. Plxna4(-/...
متن کاملToll-like receptor 9 is required for chronic stress-induced immune suppression.
OBJECTIVES Mental and physical stress can suppress the immune system in both humans and animals. The mechanism by which stress affects immune responses, however, remains poorly defined. Toll-like receptors (TLRs) play a key role in modulating immune responses and cell survival. The mechanisms by which TLRs modulate chronic stress are largely unexplored. METHODS Six- to 8-week-old male mice we...
متن کاملToll-like receptor 2 is required for optimal control of Listeria monocytogenes infection.
The control of Listeria monocytogenes infection depends on the rapid activation of the innate immune system, likely through Toll-like receptors (TLR), since mice deficient for the common adapter protein of TLR signaling, myeloid differentiation factor 88 (MyD88), succumb to Listeria infection. In order to test whether TLR2 is involved in the control of infections, we compared the host response ...
متن کاملToll-like receptor 2 is required for control of pulmonary infection with Francisella tularensis.
Toll-like receptor 2 (TLR2) deficiency enhances murine susceptibility to infection by Francisella tularensis as indicated by accelerated mortality, higher bacterial burden, and greater histopathology. Analysis of pulmonary cytokine levels revealed that TLR2 deficiency results in significantly lower levels of tumor necrosis factor alpha and interleukin-6 but increased amounts of gamma interferon...
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ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 2010
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2009.11.074